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Reaction to substance test cases

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Revision as of 02:52, 28 June 2013 by KevinCoonanMD (talk | contribs) (Page creation)
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Have a library of substances and defined case examples of hypersensitivity or propensity to adverse reaction to the substance. The reaction types need to span the spectrum, including immunologic, various signs/symptoms, non-immunologic adverse reactions including idiosyncratic reactions characteristic for a drug

Types of substances

(reaction type(s) in parenthesis)


  • codeine (fixed drug reaction, vomiting, urticaria)
  • oxycodone (vomiting, urticaria, sedation)
  • fentanyl (muscle rigidity, sedation, vomiting)
  • vecuronium (anaphylaxis)
  • succinylcholine (neuromuscular malignant syndrome, prolonged paralysis due to plasma pseudocholinesterase)
  • amoxicillin (non-specific viral infection associated rash, anaphylaxis, antibiotic associated diarrhea)
  • cephalexin (antibiotic associated diarrhea)
  • cefaclor (bleeding, rash)
  • pen VK
  • pen G
  • chloramphenicol (pancytopenia/aplastic anemia)
  • trimethoprim/sulfamethoxazole (granulocytopenia, renal injury, erythema multiforme)
  • benzathine penicillin
  • gentamicin (weakness, renal injury)
  • procaine penicillin
  • procainamide
  • procaine
  • lidocaine
  • aspirin (triad asthma, anaphylactoid syndrome, upper GI bleeding, epistaxis)

Food items

  • monosodium glutamate
  • Yellow dye #5
  • Red dye #40
  • wheat

Non-food plants

Plant derived materials

  • latex rubber

Non-drug/non-food items found in healthcare setting

  • intravenous contrast agent
  • topical disinfectant
  • medical tape


  • Yellow jacket (wasp) venom
  • Cats (atopic rhinitis)
  • House dust mites


  • Bird waste
  • Feathers

Household and Industrial Chemicals

  • Chromic acid (skin burns)
  • Sodium dichromate (contact hypersensitivity)


  • Mycoplasma pneumoniae (cold agglutinin hemolytic anemia)


  • Ni (contact hypersensitivity)