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Difference between revisions of "Reaction to substance test cases"

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=Goal=
 
=Goal=
Have a library of substances and defined case examples of hypersensitivity or propensity to adverse reaction to the substance.  The reaction types need to span the spectrum, including immunologic, various signs/symptoms, non-immunologic adverse reactions including idiosyncratic reactions characteristic for a drug
+
Have a library of substances and defined case examples of hypersensitivity or propensity to adverse reaction to the substance.  The reaction types need to span the spectrum, including immunologic, various signs/symptoms, non-immunologic adverse reactions including idiosyncratic reactions characteristic for a drug.
 +
 
 +
For each case, need to indicate:
 +
 
 +
*history of prior reactions (Care Record Entry)
 +
**evaluation
 +
**outcome
 +
**severity
 +
**treatment
 +
**manifestations
 +
**causality assessment
 +
**involved substance(s)
 +
***documentation of instance of administered/exposed material
 +
 
 +
 
 +
*diagnosis of hypersensitivity to substance (Health Concern)
 +
**substance(s) involved
 +
***certainty that correct substance is identified
 +
**prediction of criticality
 +
***probability and severity of each manifestation
 +
***temporality
 +
***ability to mitigate
 +
***ability to rescue
 +
**supporting evidence
 +
**link to care plan
 +
 
 
=Types of substances=
 
=Types of substances=
 
(reaction type(s) in parenthesis)  
 
(reaction type(s) in parenthesis)  

Revision as of 02:59, 28 June 2013

Goal

Have a library of substances and defined case examples of hypersensitivity or propensity to adverse reaction to the substance. The reaction types need to span the spectrum, including immunologic, various signs/symptoms, non-immunologic adverse reactions including idiosyncratic reactions characteristic for a drug.

For each case, need to indicate:

  • history of prior reactions (Care Record Entry)
    • evaluation
    • outcome
    • severity
    • treatment
    • manifestations
    • causality assessment
    • involved substance(s)
      • documentation of instance of administered/exposed material


  • diagnosis of hypersensitivity to substance (Health Concern)
    • substance(s) involved
      • certainty that correct substance is identified
    • prediction of criticality
      • probability and severity of each manifestation
      • temporality
      • ability to mitigate
      • ability to rescue
    • supporting evidence
    • link to care plan

Types of substances

(reaction type(s) in parenthesis)

Drugs

  • codeine (fixed drug reaction, vomiting, urticaria)
  • oxycodone (vomiting, urticaria, sedation)
  • fentanyl (muscle rigidity, sedation, vomiting)
  • vecuronium (anaphylaxis)
  • succinylcholine (neuromuscular malignant syndrome, prolonged paralysis due to plasma pseudocholinesterase)
  • amoxicillin (non-specific viral infection associated rash, anaphylaxis, antibiotic associated diarrhea)
  • cephalexin (antibiotic associated diarrhea)
  • cefaclor (bleeding, rash)
  • pen VK
  • pen G
  • chloramphenicol (pancytopenia/aplastic anemia)
  • trimethoprim/sulfamethoxazole (granulocytopenia, renal injury, erythema multiforme)
  • benzathine penicillin
  • gentamicin (weakness, renal injury)
  • procaine penicillin
  • procainamide
  • procaine
  • lidocaine
  • aspirin (triad asthma, anaphylactoid syndrome, upper GI bleeding, epistaxis)


Food items

  • monosodium glutamate
  • Yellow dye #5
  • Red dye #40
  • wheat

Non-food plants

Plant derived materials

  • latex rubber

Non-drug/non-food items found in healthcare setting

  • intravenous contrast agent
  • topical disinfectant
  • medical tape

Animals

  • Yellow jacket (wasp) venom
  • Cats (atopic rhinitis)
  • House dust mites

Environmental

  • Bird waste
  • Feathers

Household and Industrial Chemicals

  • Chromic acid (skin burns)
  • Sodium dichromate (contact hypersensitivity)

Microorganism

  • Mycoplasma pneumoniae (cold agglutinin hemolytic anemia)

Metals

  • Ni (contact hypersensitivity)