Discussion on examples and storyboard for AminoAcidSequence

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Need clarification and storyboard for examples for AminoAcidSequence (row 18)

Original Definition

DEFINITION: A representation of a linear arrangement of organic compounds containing amino (-NH2) and carboxyl (-COOH) groups.

EXAMPLE(S):  the sequence of TP53 protein, the first 20 residues of a BRCA1 protein.

OTHER NAME(S):

NOTE(S):

Ballot Comment

note this is an example and not the first 20 residues

Proposed Definition for AminoAcidSequence

DEFINITION: A representation of a linear arrangement of amino acids represented in single notation

EXAMPLE(S): AMDYSLAAAL<need all residues for whatever example is chosen based on use case> (first 20 residues of a BRCA1 protein)

OTHER NAME(S):

NOTE(S):

Proposed Disposition

Persuasive

Proposed Disposition Comment

Sounds like this might be a clarification helping to make the definition and example simpler. Need to verify the proposed change is OK with the life sciences subject matter experts who originally helped develop the LSDAM semantics to ensure their use case is correctly represented.

Initial Discussion

Consider adding a storyboard explanation of examples threaded throughout the MB classes so that there is consistency across all the classes – perhaps a section in the User Guide or a new element in the model somewhere. Somatic mutations and germline might be good candidates for this. Need SMEs to identify use cases/stories that would be most meaningful for them. Consider also adding lessons learned re given use cases.

Outstanding Question

Can someone provide a comprehensive, realistic and meaningful set of example values that uses the same overall scenario across all classes in the Molecular Biology sub-domain?

Responses

Please add your responses here...

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