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Difference between revisions of "Allergy & Intolerance Drug Sub-project"

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=Plan=
 
=Plan=
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* Confirm goals
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* Confirm goals - done
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* Assess assets
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* Assess assets - done
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* Evaluate gaps
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* Evaluate gaps - in process
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* Fill gaps
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* Fill gaps - in process
  
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=Open questions=
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[[Allergy & Intolerance substance September 2017 ballot outline | Ballot outline September 2017]]
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=Questions=
  
 
Go to [[Allergy & Intolerance Drug Sub-project questions]]
 
Go to [[Allergy & Intolerance Drug Sub-project questions]]
  
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=Closed Questions=
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=Resources=
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# Include substances only, or also null and negative values?
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* [https://www.ncbi.nlm.nih.gov/pubmed/23396542 Evaluating standard terminologies for encoding allergy information]
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## Use is the criterion: include what is used. Agreed 10/19
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* [https://www.ncbi.nlm.nih.gov/pubmed/26384406 Food entries in a large allergy data repository]
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## Specific negatives are rare; we anticipate two (nka & nkda).
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* [http://www.pss.org.sg/whats-happening/e-bulletin/issue-no-30/hypersensitivity-reactions-statins#.WVFc3Y4rKUk Statin cross-reactivity]
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# How do we confirm quality?
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* [http://www.ncpdp.org/members/pdf/20110522.NCPDP.AllergyClass.Recommendation.to.ONC-NCVHS.pdf NCPDP Recommendations]
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## Process
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* [https://www.ncbi.nlm.nih.gov/pubmed/15298998 Alert Override Results]
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### Acquire maps.  
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* [https://www.ncbi.nlm.nih.gov/pubmed/26578227 Rising Alert Overrides]
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### If count(maps) > 1 and they agree, status is ok.  
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* [https://www.ncbi.nlm.nih.gov/pubmed/23748627 Automated substance identification]
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### If count(maps) < 2,  acquire more maps.
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* [https://www.ncbi.nlm.nih.gov/pubmed/17068355 CPOE & CDS]
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### If count(maps) > 1 and they disagree, review.
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* [guidance on egg content of vaccines]
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# Encode and then combine, or combine and then encode?
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* [[Media: Presentation_HL7_allergy_and_intolerance_drug_sub-project_-_v20170630.ppt | Dutch presentation on surveillance]]
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## Encoding is required to combine
 
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# How do we weight lists?
 
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## Use filtered rankings to assess divergence, but no weighting in frequency list.
 
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# Rank all substances from contributed lists, or only those to a chosen level (97%, 99%, etc.)?
 
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## Identified substances with counts > 500 (individually ~0.0017%; aggregate 0.71%)
 
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## Actually, 1000. 4/19/17.
 
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## Include frequency ratios in resulting list; users may choose their own thresholds.
 
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# Salt forms of medications are not relevant to the purpose of this list. Incidences recorded as salt forms should be summed to the incidence of the general form (e.g., codeine sulfate as codeine).  
 
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## Salts in solution have limited effect on the active moiety. This does not mean that an intolerance reaction dependent on a salt is not possible; only that it is not common enough to merit inclusion in this list.
 
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# Route can be significant.
 
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## Enterally administered aspirin does not cross-react with topical salycilates. Topical salycilates should be specified as topical. Similarly, sensitivity to topical iodine preparations is not cross-reactive with intravenously administered iodine.
 
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### confirm cross-reactivity. whether iodine can be the problem is a different question.
 
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# What system(s) should be used for encoding?
 
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## Assumption: do we need to choose, or can we provide a list of substances with all pertinent code assignments?
 
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## Criteria
 
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### Maximal coverage of identified requirements
 
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### Ability to add missing items
 
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### Freely available
 
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### International
 
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## Candidates
 
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### SNOMED CT: substances, classes; mixtures only as products. Licensing issue.
 
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### RxNorm: substances & mixtures. No license issue, but US realm.
 
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### NDF-RT: classes only. Class definitions problematic.
 
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### UNII: substances only. US realm. no relationships (e.g., of salts)
 
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### ATC: classes only. Class definitions problematic.
 
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### INN: no access to list; tbd
 
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### Proposal to use whatever G-SRS chooses to use. Will evaluate when available.
 
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## Answer: for now, RxNorm (substances - IN & mixtures - PIN) and SNOMED CT (classes) meet our needs. When G-SRS can provide data for comparison and testing, we can confirm whether it also meets our needs and decide whether to map or replace the US realm list.
 
  
 
=Minutes=
 
=Minutes=
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 +
[[2018-04-25PC_DrugAllergySubstance_Call_Minutes | 25 April 2018]]
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[[2018-04-11PC_DrugAllergySubstance_Call_Minutes | 11 April 2018]]
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[[2018-03-28PC_DrugAllergySubstance_Call_Minutes | 28 March 2018]]
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[[2018-03-14PC_DrugAllergySubstance_Call_Minutes | 14 March 2018]]
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[[2017-06-30PC_DrugAllergySubstance_Call_Minutes | 30 June 2017 (ad hoc)]]
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[[2017-06-28PC_DrugAllergySubstance_Call_Minutes | 28 June 2017]]
  
 
[[May_2017_WGM_Madrid,_Spain:_May_6_to_May_12#Patient_Care_Wednesday_Q4 | 9 May 2017]]
 
[[May_2017_WGM_Madrid,_Spain:_May_6_to_May_12#Patient_Care_Wednesday_Q4 | 9 May 2017]]

Latest revision as of 21:15, 25 April 2018

Back to Allergy & Intolerance

Purpose

Produce a list of unique substances and multiple substance medications used in allergy & intolerance lists, ordered by frequency of incidence. This list will support the use of common elements for data capture and validation of data exchange. This list is not intended to prevent the recording of unusual substances where necessary, whether by code or text.

We would like to provide a set of standard coded identifiers for these substances. The codes for such a list would need to be free, readily available, and accepted for use by international stakeholders.

Note that the criterion is clinical use, not chemical specificity. I.e., if all we know is that the patient reports an allergy to "fish," that's what we can record. Similarly, if a patient has a reaction to percocet, and the clinician doesn't have evidence that supports identification of a specific ingredient, then "percocet" is what we know.

Goal

  • A list of substances ordered by frequency of incidence, with frequency ratios
  • Identifiers for these substances, using freely available standard identifiers

Plan

  • Confirm goals - done
  • Assess assets - done
  • Evaluate gaps - in process
  • Fill gaps - in process

Ballot outline September 2017

Questions

Go to Allergy & Intolerance Drug Sub-project questions

Resources

Minutes

25 April 2018

11 April 2018

28 March 2018

14 March 2018

30 June 2017 (ad hoc)

28 June 2017

9 May 2017

12 April 2017

8 March 2017

2 February 2017

11 January 2017

28 December 2016

14 December 2016

16 November 2016

2 November 2016

19 October 2016

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