Clarification on comments re MessengerRNA

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Need clarification on comments re MessengerRNA (row 31)

Current Definition

DEFINITION: A representation of a member of the class of RNA molecules in public resources (e.g., NCBI RefSeq or EBI Ensembl) that contains protein-coding information in its nucleotide sequence.

EXAMPLE(S): A messenger RNA/transcript record from ENSEMBL: http://www.ensembl.org/Homo_sapiens/Transcript/Summary?db=core;t=ENST00000357654

OTHER NAME(S):

NOTE(S):

Ballot Comment

The example lists a cDNA transcript. DNA analysis reports on cDNA transcripts. The class should be changed to reflect this. Also cDNA will link to the variant representation better as it uses ATCG not AUCG. Uracil is substituted for thymine. If this is for RNA testing, then how does a lab report on cDNA transcripts?

Current Disposition

Pending Input From Submitter

Proposed Disposition Comment

Need clarification - Is it the URL that lists a cDNA transcript? Need CG and LSDAM SMEs to reconcile comments with definitions/examples to provide updated text.

Outstanding Questions

• Are the class name, definition and example inconsistent with one another?
• Assuming the class name accurately reflects what was originally intended, What should the definition be?
• Assuming the class name accurately reflects what was originally intended, What should the example be?

Responses

Please add your responses here...

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