CG Working Group Meeting Minutes

Meeting Minutes - HL7 WGM

• HL7 WGM Vancouver May 2012

Tues Q3 – Amnon Shabo, Bob Milius, Jill Kaufman, Joyce Hernandez, Phil Pochon, Grant Wood

Jill suggests that the CG WG consider doing a CME tutorial at the next WGM in Baltimore. Amnon reviews the agenda. Joyce suggests we get AP more involved in Omics DAM development. Amnon gives a quick description of the new HL7 initiative called FHIR. A deeper discussion is scheduled for Wed Q2. Amnon also givse a quick description of an outside effort called iPOP. A deeper discussion is scheduled for Thurs Q2. He then went through a review of CG activities. Joyce had a question about O&O Lab 3.0 and genetic variation. Phil shared related efforts with CDISC and RCRIM.

Tues Q4 - Amnon Shabo, Bob Milius, Joyce Hernandez, Phil Pochon, Lisa Schick, Grant Wood

Amnon continued his slides on CG activities, reviewing CG CMETs and the Pedigree specification. The Pedigree model was successfully reaffirmed in HL7 balloting, with Release 2 and an Implementation Guide in progress. The V2 Implementation Guides publishing status was given by Grant. Offcial HL7 publishing forms have been completed, and the TSC will (likely) approve the guides at their next meeting. Amnon reviewed the CG DAMs (Clinical genomics including gene expression, and clinical sequencing). Amnon concluded with a review of CG work on clinical sequencing workflows and use cases - from summary slides written by Mollie.

Bob presented his work on HLA tissue typing. This comes from the NMDP matching program, and interest in adopting HL7 standards (CDA GTR) to transmit and receive electronic data with transplant sites. He gave an explanation of the NMDP HLA tissue typing nomenclature version 3. Their Allele types cover up to 6 exons and 800 SNPs. Bob reviewed the NMDP gold and silver standards for reporting data. He showed how he is attempting to put this data into a CDA GTR and Genetic Variation message. They have 150,000 allele codes, but are looking for a different code format. They are looking to use GL Strings for the report, and QR codes that can take you back to the original sequence.

Wed Q1 – Amnon Shabo, Joyce Hernandez, Phil Pochon, Lisa Schick, Grant Wood

This was a joint meeting with O&O and AP. AP is discussing using the same unique identifier throughout the sample collection, sample prep, lab accession, and result reporting process. They are discussing using a dumb (random number) or smart identifier (meta data, code that describes the specimen). Either way, the container is what is labeled.

Wed Q2 - Amnon Shabo, Joyce Hernandez, Lisa Schick, Grant Wood

Amnon reviewed the status of CDA GTR. Joyce suggested separating human and viral genomics in the Genetic Variation section. Amnon describes the concept of clinical genetic statements. He suggests we consider doing dynamic binding of answer lists. Amnon then reviwed what he calls the Layout Challenge, the question of the separation of CDA rendering and logic. A motion was made to adopt GTR sections, get LOINC codes for those sections, then offer style sheets (CAP, ACMG, JMD). the motion received no objections. Amnon plans to do tissue typing pilot with Bob and two transplant centers. Grant plans to do a pilot with Pathology group at Intermountain, and hopefully Myriad and ARUP. Don Rule has also talked about doing a CDA GTR pilot on previous CG calls.

Family history in Meaningful Use Stage 2 was discussed. Amnon continued slides that reveiwed the Pedigree Release 2 Implementation Guide work, the question of Pedigree and the new HL7 FHIR. Joyce commented that the IG should show how to move from CCD to full Pedigree. Amnnon slides will be posted to the website.

Wed Q3 - Amnon Shabo, Joyce Hernandez, Phil Pochon, Lisa Schick, Grant Wood, Elaine Ayers (NIH)

Omics DAM ballot reconciliation and comments were addressed. There was not enough time to complete this process.

Wed Q4

Joint meeting with AP.

• HL7 WGM Rio May 2010

 Media:HL7_WGM_Rio_2010_as.doc

• HL7 WGM Phoenix Jan 2010

 Media:HL7 CG WGM Phoenix 2010_latest.doc

• HL7 WGM Orlando Jan 2009

 Media:HL7_WGM_Orlando_2009_Jan15.doc