Proposed Change on Protein Definition

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Proposed Change on Protein Definition (row 55)

Original Definition

DEFINITION: A representation of an organic macromolecule in public resources (e.g., UniProt or NCBI RefSeq) composed of one or more chains (linear polymers) of alpha-L-amino acids linked by peptide bonds and ranging in size from a few thousand to over 1 million Daltons.

Comment Requested: In interest of re-using existing standards, should the above definition of Protein be replaced by the following from the NLM -- : A molecule made up of amino acids that are needed for the body to function properly. Proteins are the basis of body structures such as skin and hair and of substances such as enzymes, cytokines, and antibodies. [Source: http://ghr.nlm.nih.gov/glossary=protein]

EXAMPLE(S): A protein record from UniProt Knowledgebase: http://www.uniprot.org/uniprot/P38398

OTHER NAME(S):

NOTE(S):

Ballot Comment

Not all proteins are in a public electronic resource. The definition of minimum protein size should be based on number of residues, not molecular weight, because different amino acids have different molecular weights.

Proposed Definition

DEFINITION: A representation of an organic macromolecule composed of one or more chains (linear polymers) of alpha-L-amino acids linked by peptide bonds and ranging in size from a few dozen amino acid residues to many more.

EXAMPLE(S): A protein record from UniProt Knowledgebase: http://www.uniprot.org/uniprot/P38398

OTHER NAME(S):

NOTE(S)

Proposed Disposition

Persuasive

Proposed Disposition Comment

Review proposed change with LSDAM SMEs to ensure change is consistent with their original use case for the concept. Also see disposition comments and recommendation on Gene item a few rows above.

Outstanding Questions

• Life Science SMEs: Is the proposed change consistent with the original use case for your concept?
• Anyone: Can someone provide a comprehensive, realistic and meaningful set of example values that uses the same overall scenario across all classes in the Molecular Biology sub-domain?

Responses

Lauren Becnel: Class is accurate as is.

(NO CHANGE NEEDED)

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