View source for Discussion on examples and storyboard for AminoAcidSequence

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===Need clarification and storyboard for examples for AminoAcidSequence (row 18)===

====Original Definition for AminoAcidSequence====

DEFINITION:  A representation of a linear arrangement of organic compounds containing amino (-NH2) and carboxyl (-COOH) groups.

EXAMPLE(S):  the sequence of TP53 protein, the first 20 residues of a BRCA1 protein. 

OTHER NAME(S):

NOTE(S):

====Ballot Comment====  
note this is an example and not the first 20 residues

====Proposed Definition for AminoAcidSequence====

DEFINITION:  A representation of a linear arrangement of amino acids represented in single notation

EXAMPLE(S):  AMDYSLAAAL<need all residues for whatever example is chosen based on use case>  (first 20 residues of a BRCA1 protein)

OTHER NAME(S):

NOTE(S):

====Proposed Disposition====  
Persuasive

====Proposed Disposition Comment====  
Sounds like this might be a clarification helping to make the definition and example simpler.  Need to verify the proposed change is OK with the life sciences subject matter experts who originally helped develop the LSDAM semantics to ensure their use case is correctly represented.

====Initial Discussion====  
Consider adding a storyboard explanation of examples threaded throughout the MB classes so that there is consistency across all the classes – perhaps a section in the User Guide or a new element in the model somewhere.  Somatic mutations and germline might be good candidates for this.  Need SMEs to identify use cases/stories that would be most meaningful for them.  Consider also adding lessons learned re given use cases.

====Outstanding Question====
Can someone provide a comprehensive, realistic and meaningful set of example values that uses the same overall scenario across all classes in the Molecular Biology sub-domain?

====Responses====
Please add your responses here...


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